ʻO ke ʻano hana hou no ka mālama ʻana i ka rosacea me ka hoʻohana ʻana i ka ʻenehana pulse kūpono: In vivo a me nā haʻawina lapaʻau

Ka Moolelo:He maʻi ʻili mumū mau ka Rosacea e hoʻopilikia ana i ka maka, a ʻaʻole maikaʻi ka hopena o ka lāʻau lapaʻau o kēia manawa. Ma muli o ke photomodulation o ka ʻenehana pulse kūpono (OPT), ua hoʻomohala mākou i kahi ʻano lāʻau lapaʻau hou, ʻo ia hoʻi, ʻo OPT holomua me ka ikehu haʻahaʻa, ʻekolu pulse, a me ka laulā pulse lōʻihi (AOPT-LTL).

Nā Pahuhopu:Ua manaʻo mākou e ʻimi i ka hiki ke hana a me nā ʻano hana molekala ma lalo o ka mālama ʻana iā AOPT-LTL i loko o kahi kumu hoʻohālike ʻiole e like me rosacea. Eia kekahi, ua loiloi mākou i ka palekana a me ka pono i nā poʻe maʻi me ka erythematotelangiectatic rosacea (ETR).

Nā mea hana a me nā ʻano hana:Ua hoʻohana ʻia nā loiloi morphological, histological, a me immunohistochemical e noiʻi i ka pono a me nā ʻano hana o ka mālama ʻana iā AOPT-LTL i loko o ke kumu hoʻohālike ʻiole rosacea-like LL-37. Eia kekahi, ua hoʻokomo ʻia he 23 mau maʻi me ETR a loaʻa i nā manawa like ʻole o ka mālama ʻana ma nā manawa o 2 mau pule ma muli o ke koʻikoʻi o ko lākou kūlana. Ua loiloi ʻia ka hopena o ka mālama ʻana ma ka hoʻohālikelike ʻana i nā kiʻi lapaʻau ma ka baseline, 1 pule, a me 3 mau mahina ma hope o ka mālama ʻana, i hui pū ʻia me ka waiwai ʻulaʻula, GFSS, a me nā helu CEA.

Nā Hualoaʻa:Ma hope o ka mālama ʻana o AOPT-LTL i nā ʻiole, ua ʻike mākou ua hoʻomaikaʻi nui ʻia ke ʻano like me ka rosacea, ka infiltration cell inflammatory, a me nā ʻano ʻē o ke koko, a ua kāohi nui ʻia ka hōʻike ʻana o nā molekala koʻikoʻi o ka rosacea. I loko o ke aʻo ʻana i ke kauka, ua hoʻokō ka mālama ʻana o AOPT-LTL i nā hopena therapeutic maikaʻi i ka erythema a me ka flushing o nā maʻi ETR. ʻAʻohe hanana ʻino koʻikoʻi i ʻike ʻia.

Nā hopena:He ala palekana a maikaʻi hoʻi ʻo AOPT-LTL no ka mālama ʻana i ka ETR.