ʻO ka ʻenehana hou no ka mālama ʻana i ka rosacea me ka hoʻohana ʻana i ka ʻenehana pulse maikaʻi loa: In vivo a me nā haʻawina lapaʻau

Ka hope:ʻO Rosacea kahi maʻi ʻili ʻili maʻamau e pili ana i ka maka, a ʻaʻole ʻoluʻolu ka hopena o kēia manawa. Ma muli o ka photomodulation o ka ʻenehana pulse maikaʻi loa (OPT), ua hoʻomohala mākou i kahi ʻano hana lapaʻau hou, ʻo ia hoʻi, ʻo OPT kiʻekiʻe me ka ikehu haʻahaʻa, ʻekolu puʻupuʻu, a me ka laulā pulse lōʻihi (AOPT-LTL).

Pahuhopu:Ua manaʻo mākou e ʻimi i ka hiki a me nā ʻano molekala lalo o ka mālama ʻana i ka AOPT-LTL ma kahi ʻano ʻiole like me ka rosacea. Eia kekahi, ua loiloi mākou i ka palekana a me ka pono i nā maʻi me ka erythematotelangiectatic rosacea (ETR).

Nā mea a me nā ʻano hana:Ua hoʻohana ʻia nā kānana Morphological, histological, a immunohistochemical no ka noiʻi ʻana i ka maikaʻi a me nā hana o ka mālama ʻana i ka AOPT-LTL i ka LL-37-induced rosacea-like mouse model. Eia kekahi, ua hoʻokomo ʻia nā maʻi maʻi 23 me ka ETR a loaʻa i nā manawa like ʻole o ka mālama ʻana i nā manawa o 2 mau pule ma muli o ke koʻikoʻi o ko lākou kūlana. Ua loiloi ʻia ka hopena lapaʻau ma ka hoʻohālikelike ʻana i nā kiʻi lapaʻau ma ka baseline, 1 pule, a me 3 mahina ma hope o ka mālama ʻana, i hui pū ʻia me ka waiwai ʻulaʻula, GFSS, a me nā helu CEA.

Nā hualoaʻa:Ma hope o ka hoʻomaʻamaʻa ʻana o AOPT-LTL i nā ʻiole, ʻike mākou ua hoʻomaikaʻi nui ʻia ka rosacea-like phenotype, inflammatory cell infiltration, a me nā abnormalities vascular, a ua kāohi nui ʻia ka hōʻike ʻana o nā molekele kumu o ka rosacea. I loko o ke aʻo ʻana, ua hoʻokō ka lāʻau AOPT-LTL i nā hopena lapaʻau maikaʻi ma luna o ka erythema a me ka flushing o nā maʻi ETR. ʻAʻole i ʻike ʻia nā hanana koʻikoʻi.

Nā hopena:ʻO AOPT-LTL kahi ala palekana a maikaʻi no ka mālama ʻana i ka ETR.