ʻO nā mea hoʻonani keʻokeʻo a me ka Metabolism Pigment

ʻO nā mea hoʻonani keʻokeʻo a mePigmentʻO ka metabolism

Hoʻokaʻawale ʻia ʻo Melanin anabolism i nā manawa like ʻole. Manaʻo nā kānaka ʻepekema he hiki ke aʻo i nā mea hana keʻokeʻo a hana no nā manawa metabolic like ʻole.

(1) Ka wā mua o ka hana ʻana o ka melanin

① Hoʻopilikia i ka transcription a / a i ʻole glycosylation o tyrosinase; ② Kāohi i nā regulators i ka hoʻokumu ʻana o tyrosinase; ③ Ka hoʻomalu ʻana o ka tyrosinase ma hope o ka unuhi ʻana.

(2) Ka wā hoʻohui melanin
Ma ke ʻano o ka enzyme kī a me ka hoʻokaʻawale ʻana i ka enzyme no ka melanin synthesis, ʻo ka tyrosinase inhibitors ke kumu noiʻi a me ka hoʻomohala ʻana i kēia manawa. No ka mea, ʻo ka hapa nui o nā mea keʻokeʻo e like me ka phenol a me nā derivatives catechol e like me ka tyrosine a me ka dopa, ua helu pinepine ʻia nā mea keʻokeʻo i hoʻopaʻa ʻia ma ke ʻano he mea hoʻokūkū hoʻokūkū ʻole o tyrosinase.

(3) Ka pae hope o ka hana ʻana o ka melanin

①Hoʻopau i ka hoʻoili melanosome; nā mea me ka serine protease inhibitory hopena, e like me rwj-50353, pale loa i ka UBV-induced epidermal pigmentation; He hopena keʻokeʻo ʻo ka soybean trypsin inhibitor akā ʻaʻohe hopena i ka ʻawaʻawa o nā cell pigment; Niacinamide, hiki ke pale i ka lawe ʻana o nā melanocytes ma waena o nā melanocytes a me nā keratinocytes; ② Melanin dispersion a me ka metabolism, α-hydroxy acid, free fatty acid a me retinoic acid, hoʻoulu i ka hana hou o ka cell a hāpai i nā keratinocytes melaninized o ka wehe ʻana.

He mea pono e hoʻomaopopo i ka noiʻi a me ka hoʻohana ʻana i nā mea keʻokeʻo e pili ana i ka melanin metabolism ma luna nei ʻaʻole kūpono no ka pale ʻana a me ka mālama ʻana i nā papa senile. No ka mea pili ka hana o ka hana ʻana o ka senile plaque i ka hoʻokumu ʻana o ka lipofuscin, hoʻohana mau ʻia nā mea hana antioxidative e hoʻopaneʻe a hoʻohuli i nā papa senile.